Analysis of Human Antibodies
The Colony Lift Binding Assay (shown below) demonstrates how panels of clones, all with the identical specificity, are produced; however, the composition and physical characteristics of each clone is distinct, affording ample opportunity to screen for clones containing all the desired properties of the target therapeutic.
Clones are selected for Ka, Kd, closeness-to-human germline, stability, expression, aggregation, etc. Below are shown the aggregation profiles (SEC-HPLC) for five Humaneered® clones. Two clones show undetectable aggregation and will be included for further analysis on the screening cascade.
Pipeline
KaloBios' pipeline is comprised of first or best-in-class antibody therapeutic candidates for cancers.